Format

Send to

Choose Destination
Biochem Biophys Res Commun. 2015 Apr 24;460(1):40-9. doi: 10.1016/j.bbrc.2015.02.110.

Store-operated calcium entry: Mechanisms and modulation.

Author information

1
La Jolla Institute for Allergy & Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Electronic address: phogan@liai.org.
2
La Jolla Institute for Allergy & Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. Electronic address: arao@liai.org.

Abstract

Store-operated calcium entry is a central mechanism in cellular calcium signalling and in maintaining cellular calcium balance. This review traces the history of research on store-operated calcium entry, the discovery of STIM and ORAI as central players in calcium entry, and the role of STIM and ORAI in biology and human disease. It describes current knowledge of the basic mechanism of STIM-ORAI signalling and of the varied mechanisms by which STIM-ORAI signalling can be modulated.

KEYWORDS:

CRAC current; Calcium channel; ORAI1; STIM1; Store-operated calcium entry

PMID:
25998732
PMCID:
PMC4441756
DOI:
10.1016/j.bbrc.2015.02.110
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center