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Br J Nutr. 2015 Jul 14;114(1):1-14. doi: 10.1017/S0007114515001452. Epub 2015 May 22.

The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action.

Author information

1
Centre of Excellence in Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University,270 Joondalup Drive,Joondalup,WA6027,Australia.
2
Department of Wine,Food and Molecular Biosciences, Centre for Food Research and Innovation, Lincoln University,Lincoln,New Zealand.
3
Department of Nutrition, Dietetics and Food Technology, School of Public Health,Curtin University,WA,Australia.

Abstract

Coconut, Cocos nucifera L., is a tree that is cultivated to provide a large number of products, although it is mainly grown for its nutritional and medicinal values. Coconut oil, derived from the coconut fruit, has been recognised historically as containing high levels of saturated fat; however, closer scrutiny suggests that coconut should be regarded more favourably. Unlike most other dietary fats that are high in long-chain fatty acids, coconut oil comprises medium-chain fatty acids (MCFA). MCFA are unique in that they are easily absorbed and metabolised by the liver, and can be converted to ketones. Ketone bodies are an important alternative energy source in the brain, and may be beneficial to people developing or already with memory impairment, as in Alzheimer's disease (AD). Coconut is classified as a highly nutritious 'functional food'. It is rich in dietary fibre, vitamins and minerals; however, notably, evidence is mounting to support the concept that coconut may be beneficial in the treatment of obesity, dyslipidaemia, elevated LDL, insulin resistance and hypertension - these are the risk factors for CVD and type 2 diabetes, and also for AD. In addition, phenolic compounds and hormones (cytokinins) found in coconut may assist in preventing the aggregation of amyloid-β peptide, potentially inhibiting a key step in the pathogenesis of AD. The purpose of the present review was to explore the literature related to coconut, outlining the known mechanistic physiology, and to discuss the potential role of coconut supplementation as a therapeutic option in the prevention and management of AD.

KEYWORDS:

Alzheimer's; Amyloid; Coconut; Diabetes; Saturated fat

PMID:
25997382
DOI:
10.1017/S0007114515001452
[Indexed for MEDLINE]

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