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Clin Transl Sci. 2015 Oct;8(5):558-62. doi: 10.1111/cts.12293. Epub 2015 May 21.

Bioengineered Corneas Grafted as Alternatives to Human Donor Corneas in Three High-Risk Patients.

Author information

1
Filatov Institute of Eye Diseases and Tissue Therapy of the, National Academy of Medical Sciences of Ukraine, Odessa, Ukraine.
2
Integrative Regenerative Medicine Center, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
3
Department of Neurosciences, Swedish Medical Nanoscience Center, Karolinska Institutet, Stockholm, Sweden.

Abstract

Corneas with severe pathologies have a high risk of rejection when conventionally grafted with human donor tissues. In this early observational study, we grafted bioengineered corneal implants made from recombinant human collagen and synthetic phosphorylcholine polymer into three patients for whom donor cornea transplantation carried a high risk of transplant failure. These patients suffered from corneal ulcers and recurrent erosions preoperatively. The implants provided relief from pain and discomfort, restored corneal integrity by promoting endogenous regeneration of corneal tissues, and improved vision in two of three patients. Such implants could in the future be alternatives to donor corneas for high-risk patients, and therefore, merits further testing in a clinical trial.

KEYWORDS:

collagen; epithelium; grafting; patients; remodeling; transplantation

PMID:
25996570
PMCID:
PMC4676913
DOI:
10.1111/cts.12293
[Indexed for MEDLINE]
Free PMC Article

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