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Neuron. 2015 May 20;86(4):853-855. doi: 10.1016/j.neuron.2015.05.014.

Using opioid receptors to expand the chemogenetic and optogenetic toolbox.

Author information

1
Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029-6574, USA.
2
Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029-6574, USA. Electronic address: paul.kenny@mssm.edu.

Abstract

In this issue of Neuron, innovative new modifications to opioid receptors are used to expand the tools available to modulate neuronal activity. Vardy et al. (2015) describe a new "DREADD" chemogenetic tool based on the inhibitory κ opioid receptor (KORD) that can be used in conjunction with already-available DREADDs. Siuda et al. (2015) report the development of "opto-MOR," a light-activatable μ opioid receptor (MOR) chimera that can be used to better understand the complexities of MOR signaling.

PMID:
25996128
DOI:
10.1016/j.neuron.2015.05.014
[Indexed for MEDLINE]
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