Format

Send to

Choose Destination
FEBS J. 2015 Sep;282(17):3275-85. doi: 10.1111/febs.13323. Epub 2015 Jun 10.

Osmostress-induced gene expression--a model to understand how stress-activated protein kinases (SAPKs) regulate transcription.

Author information

1
Cell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.

Abstract

Adaptation is essential for maximizing cell survival and for cell fitness in response to sudden changes in the environment. Several aspects of cell physiology change during adaptation. Major changes in gene expression are associated with cell exposure to environmental changes, and several aspects of mRNA biogenesis appear to be targeted by signaling pathways upon stress. Exhaustive reviews have been written regarding adaptation to stress and regulation of gene expression. In this review, using osmostress in yeast as a prototypical case study, we highlight those aspects of regulation of gene induction that are general to various environmental stresses as well as mechanistic aspects that are potentially conserved from yeast to mammals.

KEYWORDS:

Hog1; SAPK; gene expression; mammals; osmostress; p38; stress responses; yeast

PMID:
25996081
PMCID:
PMC4744689
DOI:
10.1111/febs.13323
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center