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J Neurosci. 2015 May 20;35(20):7750-62. doi: 10.1523/JNEUROSCI.0268-15.2015.

Rhythmic auditory cortex activity at multiple timescales shapes stimulus-response gain and background firing.

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Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, G12 8QB,
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G1 1XQ, United Kingdom, and.
Neural Computation Laboratory, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, I-38068 Rovereto, Italy.


The phase of low-frequency network activity in the auditory cortex captures changes in neural excitability, entrains to the temporal structure of natural sounds, and correlates with the perceptual performance in acoustic tasks. Although these observations suggest a causal link between network rhythms and perception, it remains unknown how precisely they affect the processes by which neural populations encode sounds. We addressed this question by analyzing neural responses in the auditory cortex of anesthetized rats using stimulus-response models. These models included a parametric dependence on the phase of local field potential rhythms in both stimulus-unrelated background activity and the stimulus-response transfer function. We found that phase-dependent models better reproduced the observed responses than static models, during both stimulation with a series of natural sounds and epochs of silence. This was attributable to two factors: (1) phase-dependent variations in background firing (most prominent for delta; 1-4 Hz); and (2) modulations of response gain that rhythmically amplify and attenuate the responses at specific phases of the rhythm (prominent for frequencies between 2 and 12 Hz). These results provide a quantitative characterization of how slow auditory cortical rhythms shape sound encoding and suggest a differential contribution of network activity at different timescales. In addition, they highlight a putative mechanism that may implement the selective amplification of appropriately timed sound tokens relative to the phase of rhythmic auditory cortex activity.


LNP models; delta rhythm; information coding; network state; neural coding; receptive fields

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