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PLoS One. 2015 May 20;10(5):e0127369. doi: 10.1371/journal.pone.0127369. eCollection 2015.

Prognostic value of obesity on both overall mortality and cardiovascular disease in the general population.

Author information

1
Casas Ibáñez Primary Health Care Centre, Health Service of Castilla la Mancha, Albacete, Spain.
2
Zona IV Primary Health Care Centre, Health Service of Castilla la Mancha, Albacete, Spain.
3
Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Spain; Cátedra de Riesgo Cardiovascular, San Antonio Catholic University, Murcia, Spain.
4
Casas Ibáñez Primary Health Care Centre, Health Service of Castilla la Mancha, Albacete, Spain; Cátedra de Riesgo Cardiovascular, San Antonio Catholic University, Murcia, Spain.
5
Zona III Primary Health Care Centre, Health Service of Castilla la Mancha, Albacete, Spain.
6
Endocrinology and Nutrition Service, General Hospital, Albacete, Spain; Castilla La Mancha School of Medicine, Albacete, Spain.
7
Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Spain; Research Unit, Elda General Hospital, Elda, Spain.
8
Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Spain.

Abstract

BACKGROUND:

Obesity represents an important health problem and its association with cardiovascular risk factors is well-known. The aim of this work was to assess the correlation between obesity and mortality (both, all-cause mortality and the combined variable of all-cause mortality plus the appearance of a non-fatal first cardiovascular event) in a general population sample from the south-east of Spain.

MATERIALS AND METHODS:

This prospective cohort study used stratified and randomized two-stage sampling. Obesity [body mass index (BMI) ≥ 30 kg/m(2)] as a predictive variable of mortality and cardiovascular events was assessed after controlling for age, sex, cardiovascular disease history, high blood pressure, diabetes mellitus, hypercholesterolemia, high-density lipoprotein/triglycerides ratio, total cholesterol and smoking with the Cox regression model.

RESULTS:

The mean follow-up time of the 1,248 participants was 10.6 years. The incidence of all-cause mortality during this period was 97 deaths for every 10,000 person/years (95% CI: 80-113) and the incidence of all-cause mortality+cardiovascular morbidity was 143 cases for every 10,000 person/years (95% CI: 124-163). A BMI ≥ 35 kg/m(2) yielded a hazard ratio for all-cause mortality of 1.94 (95% CI: 1.11-3.42) in comparison to non-obese subjects (BMI <30 kg/m(2)). For the combination of cardiovascular morbidity plus all-cause mortality, a BMI ≥ 35 kg/m(2) had a hazard ratio of 1.84 (95% CI: 1.15-2.93) compared to non-obese subjects.

CONCLUSIONS:

A BMI ≥ 35 kg/m(2) is an important predictor of both overall mortality and of the combination of cardiovascular morbidity plus all-cause mortality.

PMID:
25992570
PMCID:
PMC4438865
DOI:
10.1371/journal.pone.0127369
[Indexed for MEDLINE]
Free PMC Article

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