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Bioinformatics. 2015 Sep 15;31(18):3069-71. doi: 10.1093/bioinformatics/btv313. Epub 2015 May 19.

DSigDB: drug signatures database for gene set analysis.

Author information

1
Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea.
2
Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea.

Abstract

We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an online DSigDB resource that allows users to search, view and download drugs/compounds and gene sets. DSigDB gene sets provide seamless integration to GSEA software for linking gene expressions with drugs/compounds for drug repurposing and translational research.

AVAILABILITY AND IMPLEMENTATION:

DSigDB is freely available for non-commercial use at http://tanlab.ucdenver.edu/DSigDB.

SUPPLEMENTARY INFORMATION:

Supplementary data are available at Bioinformatics online.

CONTACT:

aikchoon.tan@ucdenver.edu.

PMID:
25990557
PMCID:
PMC4668778
DOI:
10.1093/bioinformatics/btv313
[Indexed for MEDLINE]
Free PMC Article

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