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Arch Gynecol Obstet. 2015 Nov;292(5):1163-71. doi: 10.1007/s00404-015-3747-5. Epub 2015 May 20.

Myo-inositol is a promising treatment for the prevention of ovarian hyperstimulation syndrome (OHSS): an animal study.

Author information

1
Department of Obstetrics and Gynecology, Medical School, Sifa University, Sanayi cad no:7, 35100, Bornova, Izmir, Turkey. arzuturan74@yahoo.com.
2
Department of Obstetrics and Gynecology, Medical School, Celal Bayar University, 45030, Manisa, Turkey.
3
Department of Pathology, Medical School, Sifa University, Sanayi cad no:7, 35100, Bornova, Izmir, Turkey.
4
Biostatistics and Medical Informatics, Medical School, Sifa University, Ankara Cad. No:45, 35100, Bayrakli, Izmir, Turkey.
5
Molecular Medicine, Institute of Health Science, Dokuz Eylül University, Mithatpasa cad. No:1606 inciraltı yerleskesi, 35340, Balcova, Izmir, Turkey.
6
Department of Obstetrics and Gynecology, Medical School, Sifa University, Sanayi cad no:7, 35100, Bornova, Izmir, Turkey.
7
Department of Laboratory Animal Science, Medical School, Dokuz Eylul University, Mithatpasa cad. No:1606 inciraltı yerleskesi, 35340, Balcova, Izmir, Turkey.

Abstract

PURPOSE:

To evaluate the efficacy of myo-inositol (MI) pretreatment in OHSS.

METHODS:

In this experimental OHSS rat model, 42 immature Wistar albino female rats were divided into 6 groups: (1) the control group, (2) the ovarian stimulation group, (3) the OHSS group, (4) the OHSS + Metformin group, (5) OHSS + MI group, (6) OHSS + Metformin + MI group. OHSS was established after treatment with metformin and myo-inositol for 14 days, in the meanwhile the treatment of metformin and myo-inositol was also continued. All animals were killed 48 h after hCG administration and were compared in terms of vascular permeability, ovarian weight and diameter, ovarian VEGF, COX-2 and PEDF expression (immunohistochemistry), serum PEDF and estradiol (E2) levels.

RESULTS:

Vascular permeability, VEGF and COX-2 expressions were reduced in animals treated with MI and/or metformin. While PEDF expression was increased in the groups taking metformin, there was no difference in PEDF expression in the group taking MI and OHSS group. There was no significant difference in serum PEDF levels between groups. Blood E2 levels were decreased in groups treated with MI or metformin compared to the OHSS group.

CONCLUSIONS:

Our data demonstrate that myo-inositol is effective in preventing OHSS, similar to metformin. Although the two drugs are thought to act through distinct mechanisms, there is no apparent benefit to co-treatment with both drugs in an animal model of OHSS. Administration of myo-inositol prior to IVF treatment may favor the control of ovulation induction. Further studies are necessary to elucidate the mechanism of action and further support our findings.

KEYWORDS:

Metformin; Myo-inositol; Ovarian hyperstimulation syndrome; Pigment epithelium-derived factor; Vascular endothelial growth factor

PMID:
25990477
PMCID:
PMC4723627
DOI:
10.1007/s00404-015-3747-5
[Indexed for MEDLINE]
Free PMC Article

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