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J Am Geriatr Soc. 2015 May;63(5):902-9. doi: 10.1111/jgs.13390.

Changes in insulin-like growth factor-I and its binding proteins are associated with diabetes mellitus in older adults.

Author information

1
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
2
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
3
Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
4
Merck & Co., Inc., Whitehouse Station, New Jersey.
5
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
6
Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
7
Department of Biostatistics, University of Washington, Seattle, Washington.
8
Departments of Medicine and Public Health, Weill Medical College, Cornell University, New York, New York.

Abstract

OBJECTIVES:

To determine whether changes in insulin-like growth factor (IGF) protein levels are greater in participants with type 2 diabetes mellitus or worsening glycemia than in normoglycemic individuals over a 9-year follow-up period.

DESIGN:

Retrospective analysis of a cohort study.

SETTING:

Participants were recruited from North Carolina, California, Maryland, and Pennsylvania.

PARTICIPANTS:

Cardiovascular Health Study All Stars participants, a cohort study of community-dwelling adults aged 65 and older (N=897).

MEASUREMENTS:

Plasma IGF-I, IGF binding protein (IGFBP)-1, and IGFBP-3 levels were assessed and American Diabetes Association cut-points for impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and diabetes mellitus were used to classify participants at baseline (1996-97) and follow-up (2005-06).

RESULTS:

At baseline, mean age was 76.3±3.6, and 18.5% had diabetes mellitus. Participants with IFG alone and IGT plus IFG had higher IGF-I levels and lower IGFBP-1 levels than those with normoglycemia or diabetes mellitus. The greatest percentage change in IGF levels occurred in those who had diabetes mellitus at baseline (9-year changes: -9.3% for IGF-I, 59.7% for IGFBP-1, -13.4% for IGFBP-3), the smallest in individuals who remained normoglycemic at follow-up (9-year changes: -3.7% for IGF-I, 25.6% for IGFBP-1, -6.4% for IGFBP-3), and intermediate in those who were normoglycemic but developed IFG at follow-up.

CONCLUSION:

Degrees of glycemic impairment are associated with varying degrees of change in IGF protein levels. The changes observed in the diabetes mellitus group have been previously shown to be associated with heart failure, cancer, and noncancer mortality.

KEYWORDS:

diabetes mellitus; glycemic status; insulin-like growth factor

PMID:
25989565
PMCID:
PMC4438274
DOI:
10.1111/jgs.13390
[Indexed for MEDLINE]
Free PMC Article

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