Format

Send to

Choose Destination
Curr Opin Virol. 2015 Aug;13:55-60. doi: 10.1016/j.coviro.2015.03.020. Epub 2015 May 16.

Oncolytic viruses: perspectives on clinical development.

Author information

1
SillaJen Biotherapeutics, 450 Sansome Street, Suite 650, San Francisco, CA 94111, United States. Electronic address: jburke@sillajen.com.
2
University of Southern California, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue #3440, Los Angeles, CA 90033, United States.
3
Department of Molecular Medicine, Rochester, MN, United States; Mayo Clinic Cancer Center, Scottsdale, AZ, United States.
4
SillaJen Biotherapeutics, 450 Sansome Street, Suite 650, San Francisco, CA 94111, United States.

Abstract

Developing a live anti-cancer agent derived in most cases from human pathogens presents a unique set of challenges to clinical development versus those anticipated with standard chemotherapeutics and small molecules. The selection of therapeutic targets for oncolytic virus (OV) clinical development, as is true with the development of any agent for cancer therapy, requires careful consideration beyond preclinical and early clinical data, especially when multiple indications may initially appear equally promising. Further, the added complexity of the potential for infectious complications following OV therapy must be anticipated in order to efficiently and safely conduct clinical studies. As more OV enter the clinic, these issues will become increasingly important to successful OV drug development.

PMID:
25989094
DOI:
10.1016/j.coviro.2015.03.020
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center