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Molecules. 2015 May 15;20(5):8816-22. doi: 10.3390/molecules20058816.

Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network.

Author information

1
Department of Human Pathology, Policlinico Universitario, Via C. Valeria, Messina 98125, Italy. aarena@unime.it.
2
Department of Biological and Environmental Science, University of Messina, Sal. Sperone 31, Messina 98100, Italy. cbisignano@unime.it.
3
Department of Human Pathology, Policlinico Universitario, Via C. Valeria, Messina 98125, Italy. gstassi@unime.it.
4
Department of Drug Science and Products for Health, Vill. SS. Annunziata, Messina 98100, Italy. afilocamo@unime.it.

Abstract

We have investigated the effect of almond skin extracts on the production of pro-inflammatory and anti-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs). PBMCs were either infected or not by herpes simplex virus type 2 (HSV-2), with and without prior treatment with almond skin extracts. Production of IL-17 induced by HSV-2 was inhibited by natural skins (NS) treatment. NS triggered PBMC in releasing IFN-α, IFN-γ and IL-4 in cellular supernatants. These results may explain the antiviral potential of almond skins.

KEYWORDS:

HSV-2; IL-17; almond skins; cytokines

PMID:
25988612
PMCID:
PMC6272138
DOI:
10.3390/molecules20058816
[Indexed for MEDLINE]
Free PMC Article

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