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Curr Opin Cell Biol. 2015 Aug;35:91-7. doi: 10.1016/j.ceb.2015.04.017. Epub 2015 May 15.

Lipid droplet-organelle interactions: emerging roles in lipid metabolism.

Author information

1
Cambridge Institute for Medical Research, University of Cambridge, CB2 0XY Cambridge, United Kingdom.
2
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom.
3
Cambridge Institute for Medical Research, University of Cambridge, CB2 0XY Cambridge, United Kingdom. Electronic address: ss560@cam.ac.uk.

Abstract

Cellular homeostasis depends on the precisely coordinated use of lipids as fuels for energy production, building blocks for membrane biogenesis or chemical signals for intra-cellular and inter-cellular communication. Lipid droplets (LDs) are universally conserved dynamic organelles that can store and mobilize fatty acids and other lipid species for their multiple cellular roles. Increasing evidence suggests that contact zones between LDs and other organelles play important roles in the trafficking of lipids and in the regulation of lipid metabolism. Here we review recent advances regarding the nature and functional relevance of interactions between LDs and other organelles-particularly the endoplasmic reticulum (ER), LDs, mitochondria and vacuoles-that highlight their importance for lipid metabolism.

PMID:
25988547
DOI:
10.1016/j.ceb.2015.04.017
[Indexed for MEDLINE]

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