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Emerg Infect Dis. 2015 Jun;21(6):1041-4. doi: 10.3201/eid2106.140717.

Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.

Abstract

To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.

KEYWORDS:

Aspergillus; antimicrobial resistance; aspergillosis; azole resistance; fungi; international; prevalence; surveillance

PMID:
25988348
PMCID:
PMC4451897
DOI:
10.3201/eid2106.140717
[Indexed for MEDLINE]
Free PMC Article

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