Format

Send to

Choose Destination
Emerg Infect Dis. 2015 Jun;21(6):1034-7. doi: 10.3201/eid2106.141504.

KPC and NDM-1 genes in related Enterobacteriaceae strains and plasmids from Pakistan and the United States.

Abstract

To characterize the genomic context of New Delhi metallo-β-lactamase-1 (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC), we sequenced 78 Enterobacteriaceae isolates from Pakistan and the United States encoding KPC, NDM-1, or no carbapenemase. High similarities of the results indicate rapid spread of carbapenem resistance between strains, including globally disseminated pathogens.

KEYWORDS:

Carbapenems; Enterobacter; Enterobacteriaceae; Escherichia coli; Klebsiella infections; Klebsiella pneumonia; Pakistan; United States; antibiotic drugs; antimicrobial resistance; bacteria; beta-Lactam resistance; beta-Lactamases; beta-Lactams; gene transfer; genomics; multilocus sequence typing; next-generation sequencing; phylogeny; plasmids; transposases

PMID:
25988236
PMCID:
PMC4451916
DOI:
10.3201/eid2106.141504
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for CDC-NCEZID Icon for PubMed Central
Loading ...
Support Center