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Rev Med Inst Mex Seguro Soc. 2015 May-Jun;53(3):348-55.

[Copy number variation: markers and predictors for type 2 diabetes].

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades "Bernardo Sepúlveda", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal, México. mcruzl@yahoo.com.

Abstract

in English, Spanish

Type 2 diabetes (T2D) is a disease characterized by a deficiency in production or action of insulin. It is the result mainly of the interaction of the environment, lifestyle, as well as genetic factors. It is considered as one of the major health issues in the world because it affects severely the psychological well-being and overall life quality. Recently it has been shown that DNA copy number variations (CNVs) are associated with several diseases, including obesity and T2D. The CNVs are present from 9 to 18 % of the genome and can modify the expression levels of mRNA and proteins encoded by genes located near their localization. Less is known about their contribution to the pathogenesis of metabolic diseases, which is necessary to characterize so that these variations can be potentially used as biomarkers of genetic risk CNVs of T2D.

KEYWORDS:

DNA copy number variation; Single nucleotide polymorphism; Type 2 diabetes

PMID:
25984620
[Indexed for MEDLINE]

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