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Rev Med Inst Mex Seguro Soc. 2015 May-Jun;53(3):286-93.

[Cytomegalovirus: congenital infection and clinical presentation in infants with respiratory distress syndrome].

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Unidad de Cuidados Intensivos Neonatales, Hospital de Gineco-Pediatría y Medicina Familiar 31, Instituto Mexicano del Seguro Social (IMSS), Mexicali, Baja California.

Abstract

in English, Spanish

BACKGROUND:

Respiratory distress syndrome (RDS) is a multifactorial and common disease that varies from 15 to 50 % in the newborn, causing 50 % of mortality. The RDS may be associated with bacterial and viral infections, and one of the most common viral agents is the cytomegalovirus (CMV). In the neonatal period the virus incidence goes from 0.4 to 2.5 % with a seroprevalence of 50 to 75 %; the incidence of infection in newborn with RDS is unknown. The objective was to determine the frequency of CMV infection in neonates with RDS and identify the risk factors associated with infection.

METHODS:

The CMV-DNA was identified in plasma by quantitative PCR; maternal and neonatal variables that defined the clinical findings were analyzed by logistic regression.The CMV-DNA was identified in plasma by quantitative PCR; maternal and neonatal variables that defined the clinical findings were analyzed by logistic regression.

RESULTS:

The frequency of CMV infection in 197 infants with RDS was 8.6 % (95 % CI, 4.7-12.5). The significant variables in newborn were: neutropenia (p = 0.012), thrombocytopenia (p = 0.021), mottled skin (p = 0.03), and the maternal significant variable was cervicovaginitis (p = 0.05).

CONCLUSIONS:

We reported for the first time the highest frecuency of CMV infection in newborns with RDS and the association of various risk factors with CMV infection.

KEYWORDS:

Cytomegalovirus; Newborn infant; Newborn respiratory distress syndrome; Polymerase chain reaction

PMID:
25984613
[Indexed for MEDLINE]

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