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Genet Mol Biol. 2015 Mar;38(1):42-7. doi: 10.1590/S1415-475738120140179. Epub 2014 Mar 17.

Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population.

Author information

1
Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland .
2
Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland .
3
Department of Reproductive Medicine and Gynecology, Pomeranian Medical University, Szczecin, Poland .

Abstract

Spermatogenesis is a process where an important contribution of genes involved in folate-mediated one-carbon metabolism is observed. The aim of the present study was to investigate the association between male infertility and the MTHFR (677C > T; 1298A > C), MTR (2756A > G) and MTRR (66A > G) polymorphisms in a Polish population. No significant differences in genotype or allele frequencies were detected between the groups of 284 infertile men and of 352 fertile controls. These results demonstrate that common polymorphisms in folate pathway genes are not major risk factors for non-obstructive male infertility in the Polish population.

KEYWORDS:

MTHFR; MTR; MTRR; infertility; polymorphism

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