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Dis Markers. 2015;2015:643420. doi: 10.1155/2015/643420. Epub 2015 Apr 23.

Altered chromogranin A circulating levels in Meniere's disease.

Author information

1
ENT Division, San Raffaele Scientific Institute, Milan, Italy.
2
Division of Experimental Oncology, San Raffaele Scientific Institute, Milan, Italy.
3
Department of Internal Medicine and Division of Regenerative Medicine, Stem Cells & Gene Therapy, San Raffaele Scientific Institute, UniversitĂ  Vita-Salute San Raffaele, Milan, Italy.

Abstract

OBJECTIVES:

Meniere's disease (MD) is an inner ear disorder characterized by episodic vertigo, ear fullness, and hearing loss; usually vertigo attacks cluster in specific period. We studied in MD patients the circulating levels of chromogranin A (CgA) and vasostatin-1 (VS-1), secreted by the neuroendocrine system and involved in the regulation of the endothelial barrier function.

METHODS:

Serum levels were assessed in 37 MD patients and 36 controls. The ratio between VS-1 and CgA was calculated.

RESULTS:

CgA was increased in patients compared to controls (1.46 versus 0.67 nM, p = 0.01) while no difference was detected for VS-1 (0.41 versus 0.39, resp.). CgA levels in patients positively correlated with the frequency of vertigo spells in the previous four weeks (p = 0.008) and negatively with the time in days from the last vertigo attack (p = 0.018). Furthermore, the VS-1/CgA ratio negatively correlated with the frequency of vertigo spells (p = 0.029) and positively correlated with the time from the last attack (p = 0.003).

CONCLUSION:

The results indicate that variations of CgA levels, but not of VS-1, occur in the blood of patients with active MD, depending on the frequency of vertigo spells and the time from the last crisis.

PMID:
25983374
PMCID:
PMC4423029
DOI:
10.1155/2015/643420
[Indexed for MEDLINE]
Free PMC Article

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