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J Card Fail. 2015 Aug;21(8):630-41. doi: 10.1016/j.cardfail.2015.05.004. Epub 2015 May 14.

Nurse-Enhanced Computerized Cognitive Training Increases Serum Brain-Derived Neurotropic Factor Levels and Improves Working Memory in Heart Failure.

Author information

1
University of Michigan School of Nursing, Ann Arbor, Michigan. Electronic address: spressle@med.umich.edu.
2
University of Michigan School of Nursing, Ann Arbor, Michigan.
3
Division of Internal Medicine, Cardiology, University of Michigan School of Medicine, Ann Arbor, Michigan.
4
University of Michigan School of Public Health, Ann Arbor, Michigan.
5
University of Michigan College of Pharmacy, Ann Arbor, Michigan.
6
University of Maryland School of Nursing and Program in Neuroscience, Baltimore, Maryland.
7
Neuropsychology Section, Department of Psychiatry, Department of Neurology, Department of Psychology, and University of Michigan School of Nursing, Ann Arbor, Michigan.

Abstract

BACKGROUND:

Memory loss is common in heart failure (HF) patients, but few interventions have been tested to treat it. The objective of this study was to evaluate efficacy of a cognitive training intervention, Brain Fitness, to improve memory, serum brain-derived neurotropic factor (BDNF) levels, working memory, processing speed, executive function, instrumental activities of daily living, mobility, depressive symptoms, and health-related quality of life.

METHODS AND RESULTS:

Twenty-seven HF patients were randomly assigned to Brain Fitness and health education active control interventions. Data were collected at baseline and 8 and 12 weeks. Linear mixed models analyses were completed. Patients in the Brain Fitness group were older with lower ejection fraction. At 12 weeks, a group by time interaction effect was found for serum BDNF levels (P = .011): serum BDNF levels increased among patients who completed Brain Fitness and decreased among patients who completed health education. No differences were found in memory, but a group by time interaction (P = .046) effect was found for working memory.

CONCLUSIONS:

Findings support efficacy of Brain Fitness in improving working memory and serum BDNF levels as a biomarker of intervention response. A randomized controlled study is needed among a larger more diverse group of HF patients.

KEYWORDS:

BDNF; Memory loss; computerized cognitive training; health-related quality of life

PMID:
25982826
DOI:
10.1016/j.cardfail.2015.05.004
[Indexed for MEDLINE]

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