Format

Send to

Choose Destination
Eur J Pediatr. 2015 Nov;174(11):1503-9. doi: 10.1007/s00431-015-2561-1. Epub 2015 May 16.

Therapeutic superiority of combined propranolol with short steroids course over propranolol monotherapy in infantile hemangioma.

Author information

1
Pediatric Surgery Department, Ain Shams University, Cairo, Egypt. dr_medodahab@hotmail.com.
2
Pediatric Surgery Department, Ain Shams University, Cairo, Egypt. alaa_hamza@msn.com.
3
Pediatric Surgery Department, Ain Shams University, Cairo, Egypt. heshamabdelkader@yahoo.com.
4
Pediatric Surgery Department, Ain Shams University, Cairo, Egypt. hatemsaafan@yahoo.com.
5
Radiodiagnosis Department, Ain Shams University, Cairo, Egypt. mohamedshakerghazy@yahoo.com.
6
Hematology-Oncology Unit, Pediatric Department, Ain Shams University, Abbasseya Square, Cairo, Egypt. hragab68@hotmail.com.

Abstract

Infantile hemangiomas are the most common benign childhood tumor that may have functional and/or cosmetic complications. We aimed to compare the clinical efficacy of propranolol alone and propranolol primed with systemic corticosteroids on the outcome of infantile hemangioma. A prospective randomized study included 40 infants aged less than 9 months with cutaneous hemangiomas. Patients were randomly assigned into two groups: group A were given oral prednisolone for the initial 2 weeks combined with oral propranolol, while group B were given oral propranolol alone for 6 months. The median age of the studied patients was 4.5 months (ranged 4 weeks-8 months). Sequential determination of the dimensions of the hemangiomas based on direct measurement and photographic analysis were performed. A significant reduction in the size of the lesions was found in group A in the 2-, 4-, and 8-week evaluation compared to group B (p < 0.001) with no statistical difference in the ultimate 6 month response (p = 0.134). Multiple logistic regression showed that early treatment before 6 months of age (OR 9.82, p = 0.007) and combined treatment with propranolol and prednisolone (OR 10.71, p = 0.006) were the predictors of best response.

CONCLUSION:

Combining propranolol with corticosteroids gives a faster response and should be considered in treating life- or function-threatening hemangiomas.

KEYWORDS:

Combined treatment; Infantile hemangioma; Propranolol

PMID:
25982338
DOI:
10.1007/s00431-015-2561-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center