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FEBS Lett. 2015 Jun 22;589(14):1546-51. doi: 10.1016/j.febslet.2015.05.008. Epub 2015 May 14.

Function of human WIPI proteins in autophagosomal rejuvenation of endomembranes?

Author information

1
Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute of Cell Biology, Eberhard Karls University Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany.
2
Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute of Cell Biology, Eberhard Karls University Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany. Electronic address: tassula.proikas-cezanne@uni-tuebingen.de.

Abstract

Despite the availability of a large pool of experimental approaches and hypothetical considerations, the hunt for the enigmatic membrane origin of autophagosomes is still on. In mammalian cells proposed scenarios for the formation of the autophagosomal membrane include both de novo assembly, and rearrangements plus maturation of pre-existing membrane sections from the endoplasmic reticulum (ER), plasma membrane, Golgi or mitochondria. Earlier, we identified the human WD-repeat protein interacting with phosphoinositides (WIPI) family and showed that WIPI proteins function as essential phosphatidylinositol 3-phosphate (PtdIns3P) effectors at the nascent autophagosome. Interestingly, WIPI proteins localize to both pre-existing endomembranes and nascent autophagosomes. In this context, and on the basis of historical records on the formation of autophagosomes, we discuss with appropriate modesty an alternative perspective on the membrane origin of autophagosomes.

KEYWORDS:

Autophagy; Phosphatidylinositol 3-phosphate; WIPI; WIPI1; WIPI2

PMID:
25980605
DOI:
10.1016/j.febslet.2015.05.008
[Indexed for MEDLINE]
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