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Adv Drug Deliv Rev. 2015 Jun 29;87:3-14. doi: 10.1016/j.addr.2015.05.001. Epub 2015 May 12.

An overview of microRNAs.

Author information

1
Department of Cell Biology and Physiology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: hammond@med.unc.edu.

Abstract

The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in molecular biology. There are now over 2000 miRNAs that have been discovered in humans and it is believed that they collectively regulate one third of the genes in the genome. miRNAs have been linked to many human diseases and are being pursued as clinical diagnostics and as therapeutic targets. This review presents an overview of the miRNA pathway, including biogenesis routes, biological roles, and clinical approaches.

KEYWORDS:

Argonaute; Dicer; Drosha; MicroRNA; RNAi; miRNA

PMID:
25979468
PMCID:
PMC4504744
DOI:
10.1016/j.addr.2015.05.001
[Indexed for MEDLINE]
Free PMC Article
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