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FEBS Lett. 2015 Jun 22;589(14):1552-8. doi: 10.1016/j.febslet.2015.05.001. Epub 2015 May 12.

PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction.

Author information

1
Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.
2
Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy. Electronic address: emilio.hirsch@unito.it.

Abstract

The spatial restriction of phosphorylated phosphoinositides generated downstream activated membrane receptors is critical for proper cell response to environmental cues. The α isoform of class II PI3Ks, PI3K-C2α, has emerged as a modulator of receptor localization, acting both in the control of receptor endocytosis and resensitization. This unexpectedly versatile enzyme was found to differentially produce two distinct 3-phosphorylated phosphoinositides and to selectively control distinct steps of vesicular traffic such as endocytosis and recycling. This review focuses on the latest discoveries regarding PI3K-C2α function in vesicle trafficking and its impact on cell biology and mammalian embryonic development.

KEYWORDS:

Class II α-isoform of phosphatidylinositol 3-kinase; Endocytosis; Exocytosis; PI3K-C2α; Phosphoinositide; Signal transduction; Vesicle trafficking

PMID:
25979177
DOI:
10.1016/j.febslet.2015.05.001
[Indexed for MEDLINE]
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