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Nat Chem Biol. 2015 Jun;11(6):387-97. doi: 10.1038/nchembio.1809. Epub 2015 May 15.

Application guide for omics approaches to cell signaling.

Author information

1
Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
2
MRC Laboratory for Molecular Cell Biology, University College London, London, UK.
3
1] Donnelly Centre, University of Toronto, Toronto, Ontario, Canada. [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. [3] Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

Abstract

Research in signal transduction aims to identify the functions of different signaling pathways in physiological and pathological states. Traditional techniques using biochemical, genetic or cell biological approaches have made important contributions to our understanding of cellular signaling. However, the single-gene approach does not take into account the full complexity of cell signaling. With the availability of omics techniques, great progress has been made in understanding signaling networks. Omics approaches can be classified into two categories: 'molecular profiling', including genomic, proteomic, post-translational modification and interactome profiling; and 'molecular perturbation', including genetic and functional perturbations.

PMID:
25978996
DOI:
10.1038/nchembio.1809
[Indexed for MEDLINE]
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