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Comput Biol Med. 2015 Oct 1;65:229-42. doi: 10.1016/j.compbiomed.2015.04.027. Epub 2015 Apr 25.

Techniques for automated local activation time annotation and conduction velocity estimation in cardiac mapping.

Author information

1
Department of Aeronautics, Imperial College London, South Kensington Campus, London, UK; National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, UK. Electronic address: c.cantwell@imperial.ac.uk.
2
Department of Bioengineering, Imperial College London, South Kensington Campus, London, UK; National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, UK.
3
National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, UK.
4
Department of Bioengineering, Imperial College London, South Kensington Campus, London, UK.
5
Department of Aeronautics, Imperial College London, South Kensington Campus, London, UK.

Abstract

Measurements of cardiac conduction velocity provide valuable functional and structural insight into the initiation and perpetuation of cardiac arrhythmias, in both a clinical and laboratory context. The interpretation of activation wavefronts and their propagation can identify mechanistic properties of a broad range of electrophysiological pathologies. However, the sparsity, distribution and uncertainty of recorded data make accurate conduction velocity calculation difficult. A wide range of mathematical approaches have been proposed for addressing this challenge, often targeted towards specific data modalities, species or recording environments. Many of these algorithms require identification of activation times from electrogram recordings which themselves may have complex morphology or low signal-to-noise ratio. This paper surveys algorithms designed for identifying local activation times and computing conduction direction and speed. Their suitability for use in different recording contexts and applications is assessed.

KEYWORDS:

Arrhythmias; Cardiac electrophysiology; Cardiac mapping; Conduction velocity; Local activation time

PMID:
25978869
PMCID:
PMC4593301
DOI:
10.1016/j.compbiomed.2015.04.027
[Indexed for MEDLINE]
Free PMC Article
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