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J Stud Alcohol Drugs. 2015 May;76(3):414-8.

Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults.

Author information

1
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
2
Department of Actuarial and Risk Management, Karabük University, Karabük, Turkey.
3
Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri.
4
Departments of Biochemistry & Molecular Biology, Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.
5
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana.
6
Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut.
7
Department of Psychiatry and Behavioral Sciences, State University of New York (SUNY) Downstate Medical Center, Brooklyn, New York.

Abstract

OBJECTIVE:

The gene GRM8, a metabotropic glutamate receptor, has emerged as a gene of interest for its possible role in the development of alcohol dependence, with evidence of association with an electrophysiological endophenotype and level of response to alcohol as well as suggestive evidence of association with alcohol dependence.

METHOD:

The present study further investigated the association between GRM8 and alcohol dependence symptom counts among young adults using a new sample of individuals collected as part of the prospective sample (ages 18-26 years; N = 842) from the Collaborative Study on the Genetics of Alcoholism (COGA).

RESULTS:

Two single-nucleotide polymorphisms were significantly associated with alcohol dependence in European Americans using the Nyholt corrected p value of .007: rs886003 (β = -.212, p = .0002) and rs17862325 (β = -.234, p < .0001), but not in African Americans, likely because of the lower power to detect association in this group.

CONCLUSIONS:

These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence.

PMID:
25978827
PMCID:
PMC4440299
DOI:
10.15288/jsad.2015.76.414
[Indexed for MEDLINE]
Free PMC Article

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