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Soc Neurosci. 2016;11(2):140-152. doi: 10.1080/17470919.2015.1044672. Epub 2015 May 15.

Affective resonance in response to others' emotional faces varies with affective ratings and psychopathic traits in amygdala and anterior insula.

Author information

1
Division of Psychology and Language Sciences, University College London, United Kingdom.
2
CIPsi, School of Psychology, University of Minho, Portugal.
3
Department of Psychology, Royal Holloway University of London, United Kingdom.
4
Institute of Cognitive Neuroscience, University College London, United Kingdom.
#
Contributed equally

Abstract

Despite extensive research on the neural basis of empathic responses for pain and disgust, there is limited data about the brain regions that underpin affective response to other people's emotional facial expressions. Here, we addressed this question using event-related functional magnetic resonance imaging to assess neural responses to emotional faces, combined with online ratings of subjective state. When instructed to rate their own affective response to others' faces, participants recruited anterior insula, dorsal anterior cingulate, inferior frontal gyrus, and amygdala, regions consistently implicated in studies investigating empathy for disgust and pain, as well as emotional saliency. Importantly, responses in anterior insula and amygdala were modulated by trial-by-trial variations in subjective affective responses to the emotional facial stimuli. Furthermore, overall task-elicited activations in these regions were negatively associated with psychopathic personality traits, which are characterized by low affective empathy. Our findings suggest that anterior insula and amygdala play important roles in the generation of affective internal states in response to others' emotional cues and that attenuated function in these regions may underlie reduced empathy in individuals with high levels of psychopathic traits.

KEYWORDS:

Amygdala; Anterior insula; Emotional facial expression; Empathy; Psychopathic Personality; fMRI

PMID:
25978492
PMCID:
PMC5321475
DOI:
10.1080/17470919.2015.1044672
[Indexed for MEDLINE]
Free PMC Article

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