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Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. eCollection 2015.

Human olfactory receptor responses to odorants.

Author information

1
Monell Chemical Senses Center , 3500 Market Street, Philadelphia, Pennsylvania 19104, USA ; Department of Molecular Genetics and Microbiology, Duke University Medical Center , Research Drive, Durham, North Carolina 27710, USA ; Department of Neuroscience, University of Pennsylvania School of Medicine , Philadelphia, Pennsylvania 19104, USA.
2
Department of Molecular Genetics and Microbiology, Duke University Medical Center , Research Drive, Durham, North Carolina 27710, USA.
3
Department of Molecular Genetics and Microbiology, Duke University Medical Center , Research Drive, Durham, North Carolina 27710, USA ; Department of Neurobiology and Duke Institute for Brain Sciences, Duke University Medical Center , Research Drive, Durham, North Carolina 27710, USA.

Abstract

Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a clone library of 511 human olfactory receptors. This dataset will allow other researchers to interrogate the combinatorial nature of olfactory coding.

PMID:
25977809
PMCID:
PMC4412152
DOI:
10.1038/sdata.2015.2
[Indexed for MEDLINE]
Free PMC Article

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