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In Vivo. 2015 May-Jun;29(3):351-7.

No Dynamic Changes in Blood-brain Barrier Permeability Occur in Developing Rats During Local Cortex Exposure to Microwaves.

Author information

  • 1Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan Department of Environmental Health, National Institute of Public Health, Saitama, Japan bdxmsd@yahoo.co.jp.
  • 2Department of Environmental Health, National Institute of Public Health, Saitama, Japan.
  • 3Department of Computer Science and Engineering, Nagoya Institute of Technology, Aichi, Japan.
  • 4Department of Electrical and Electronics Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
  • 5Electromagnetic Compatibility Laboratory, Applied Electromagnetic Research Institute, National Institute of Information and Communications Technology, Tokyo, Japan.
  • 6Department of Electrical and Electronic Engineering, Tokyo Metropolitan University, Tokyo, Japan.
  • 7Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
  • 8Japan EMF Information Center, Tokyo, Japan.

Abstract

Little information is available about the effects of exposure to radiofrequency electromagnetic fields (RF) on cerebral microcirculation during rat developmental stages. We investigated whether the permeability of the blood-brain barrier (BBB) in juvenile and young adult rats was modified during local cortex exposure to RF under non-thermal conditions. The cortex tissue targeted was locally exposed to 1457 MHz RF at an average specific absorption rate of 2.0 W/kg in the target area for 50 min and permeability changes in the BBB of the pia mater were measured directly, using intravital fluorescence microscopy. There was no significant difference in extravasation of intravenously-injected dye between exposed and sham-exposed groups of either category of rats. No histological evidence of albumin leakage was found in any of the brains just after exposure, indicating that no traces of BBB disruption remained. These findings suggest that no dynamic changes occurred in BBB permeability of the rats at either of these developmental stages, even during local RF exposure at non-thermal levels.

KEYWORDS:

Radiofrequency electromagnetic field; blood-brain barrier; development stage; juvenile; local exposure; temperature; young adult

PMID:
25977380
[PubMed - indexed for MEDLINE]
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