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J Infect Dis. 2015 Dec 1;212(11):1719-25. doi: 10.1093/infdis/jiv281. Epub 2015 May 14.

Effect of Preexisting Serum and Mucosal Antibody on Experimental Respiratory Syncytial Virus (RSV) Challenge and Infection of Adults.

Author information

1
Department of Pediatrics, University of Tennessee Health Science Center Le Bonheur Children's Hospital, Memphis, Tennessee Children's Foundation Research Institute, Memphis, Tennessee.
2
Alnylam Pharmaceuticals, Cambridge, Massachusetts.
3
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, United Kingdom.
4
Department of Pediatrics, University of Tennessee Health Science Center.
5
University of Rochester School of Medical and Dentistry and Rochester General Hospital, New York.
6
Department of Pediatrics, University of Tennessee Health Science Center Le Bonheur Children's Hospital, Memphis, Tennessee Children's Foundation Research Institute, Memphis, Tennessee Department of Molecular Sciences, University of Tennessee Health Sciences Center, Memphis.

Abstract

We studied preexisting respiratory syncytial virus (RSV)-specific serum and nasal antibodies and their correlation with infectivity, viral dynamics, and disease severity in a human experimental infection model. Higher preinoculation serum neutralizing antibody titers and nasal immunoglobulin (Ig) A predicted lower infectivity and lower measures of viral replication. However, once individuals were infected, no significant protective effect of preexisting antibodies was seen. Lack of correlation between serum and mucosal antibodies was observed, implying that they are independent co-correlates of protection against RSV infection. We suggest that protection from RSV infection is a function of a complex interplay between mucosal and serum humoral immune responses.

KEYWORDS:

correlates of protection; mucosal antibody responses; respiratory syncytial virus; serum antibody responses; vaccines

PMID:
25977264
DOI:
10.1093/infdis/jiv281
[Indexed for MEDLINE]

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