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J Hematol Oncol. 2015 May 15;8:52. doi: 10.1186/s13045-015-0148-y.

The impact of taxane-based preoperative chemotherapy in gastroesophageal signet ring cell adenocarcinomas.

Author information

1
Department of Medical Oncology, University Hospital of Besancon, 3 Boulevard Alexander Fleming, Besancon, F-25030, France. chkim@chu-besancon.fr.
2
Clinical Investigational Centre, CIC-1431, University Hospital of Besançon, Besançon, France. chkim@chu-besancon.fr.
3
INSERM, Unit 1098, University of Franche-Comté, Besançon, France. chkim@chu-besancon.fr.
4
Department of Medical Oncology, University Hospital of Besancon, 3 Boulevard Alexander Fleming, Besancon, F-25030, France. fredericfiteni@gmail.com.
5
Methodology and Quality of Life in Oncology Unit, University Hospital of Besançon, Besançon, France. fredericfiteni@gmail.com.
6
Methodology and Quality of Life in Oncology Unit, University Hospital of Besançon, Besançon, France. spaget@chu-besancon.fr.
7
Department of Oncology, Georges-Francois Leclerc Cancer Center, Dijon, France. FGhiringhelli@cgfl.fr.
8
Department of Digestive Surgery and Liver Transplantation, University Hospital of Besançon, Besançon, France. zaher.lakkis@gmail.com.
9
Department of Medical Oncology, University Hospital of Besancon, 3 Boulevard Alexander Fleming, Besancon, F-25030, France. jary.marine@yahoo.fr.
10
INSERM, Unit 1098, University of Franche-Comté, Besançon, France. jary.marine@yahoo.fr.
11
Department of Gastroenterology, University Hospital of Besançon, Besançon, France. ffein@chu-besancon.fr.
12
Methodology and Quality of Life in Oncology Unit, University Hospital of Besançon, Besançon, France. franck.bonnetain@univ-fcomte.fr.
13
EA 3181 University of Franche-Comté, Besançon, Besançon, France. franck.bonnetain@univ-fcomte.fr.
14
Department of Digestive Surgery, Lille University Hospital, Lille, France. Christophe.mariette@chru-lille.fr.
15
Department of Medical Oncology, University Hospital of Besancon, 3 Boulevard Alexander Fleming, Besancon, F-25030, France. Christophe.borg@efs.sante.fr.
16
Clinical Investigational Centre, CIC-1431, University Hospital of Besançon, Besançon, France. Christophe.borg@efs.sante.fr.
17
INSERM, Unit 1098, University of Franche-Comté, Besançon, France. Christophe.borg@efs.sante.fr.

Abstract

The benefit of preoperative chemotherapy in resectable gastroesophageal adenocarcinomas was not observed in signet ring cell subtype. However, the potential interest of taxane-based preoperative chemotherapy on this subtype is still an unresolved issue. Nineteen patients with localized signet ring cell adenocarcinomas received taxane-based regimens, and 17 patients underwent surgery. Complete resection was achieved in 80 %, and median overall survival was 40.8 months (95 % confidence interval (CI), 20.2-not reached). Even though one patient achieved a complete pathological response, seven patients had an upstaging of their tumors at surgery. The potential benefits of taxane-based chemotherapy seem to be limited to a reduced number of patients.

PMID:
25976888
PMCID:
PMC4440289
DOI:
10.1186/s13045-015-0148-y
[Indexed for MEDLINE]
Free PMC Article

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