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Food Chem. 2015 Nov 1;186:13-9. doi: 10.1016/j.foodchem.2015.02.138. Epub 2015 Mar 6.

Inhibition effects of Chinese cabbage powder on aflatoxin B1-induced liver cancer.

Author information

1
College of Food and Biological Engineering, Qiqihar University, Qiqihar 161006, Heilongjiang, China.
2
Clinical Pathological Diagnosis Center, Qiqihar Medical University, Qiqihar 161006, Heilongjiang, China.
3
Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130022, Jilin, China. Electronic address: 56347418@qq.com.
4
Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130022, Jilin, China; School of Biological and Agricultural Engineering, Jilin University, Changchun 130022, Jilin, China. Electronic address: 5321755@qq.com.
5
School of Biological and Agricultural Engineering, Jilin University, Changchun 130022, Jilin, China.

Abstract

In this study, 0.25 μg/ml aflatoxin B1 was used to establish a liver cancer model for assessing the potential anticancer ability of Chinese cabbage powder, which is a complex water-soluble extract from Chinese cabbage by spray-drying at an outlet temperature of 130 °C. We found at least 11 potential anticancer substances in Chinese cabbage powder. A 90-d animal experiment demonstrated that 10% of Chinese cabbage powder in drinking water could improve the plasma micronutrient status, inhibit the formation of aflatoxin B1-DNA adducts in liver cells, and effectively reduce the incidence of liver tumor induced by aflatoxin B1 from 6.67% to 0%. The dose effect experiment revealed that 10% may be the minimal effective dose to prevent the occurrence of early liver tumors. This study will help elucidate the basis of epidemiological observations of dietary cancer prevention in humans, as well as explore related mechanisms.

KEYWORDS:

Aflatoxin B(1); Antitumor activities; Chinese cabbage powder; Liver tumor; Vegetable food

PMID:
25976785
DOI:
10.1016/j.foodchem.2015.02.138
[Indexed for MEDLINE]

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