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BMC Ophthalmol. 2015 May 15;15:53. doi: 10.1186/s12886-015-0036-9.

Intra-observer and inter-observer repeatability of ocular surface interferometer in measuring lipid layer thickness.

Zhao Y1, Tan CL2, Tong L3,4,5,6,7.

Author information

1
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. zhaoyang.work@gmail.com.
2
Singapore National Eye Center, 11 Third Hospital Avenue, 168751, Singapore, Singapore. carin.tan.l.s@snec.com.sg.
3
Singapore National Eye Center, 11 Third Hospital Avenue, 168751, Singapore, Singapore. Louis.tong.h.t@snec.com.sg.
4
Ocular Surface Research Group, Singapore Eye Research Institute, 168751, Singapore, Singapore. Louis.tong.h.t@snec.com.sg.
5
Department of Cornea and External Eye Disease, Singapore National Eye Center, 11 Third Hospital Avenue, 168751, Singapore, Singapore. Louis.tong.h.t@snec.com.sg.
6
Office of Clinical, Academic and Faculty Affairs, Duke-NUS Graduate Medical School, Singapore, Singapore. Louis.tong.h.t@snec.com.sg.
7
Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Louis.tong.h.t@snec.com.sg.

Abstract

BACKGROUND:

Tear lipid morphology is important for normal tear function. Recently, there have been clinical studies using interferometry to assess lipid layer thickness (LLT). The aim of the study is to examine the repeatability of a commercially available interferometer.

METHODS:

Two observers measured LLT in twenty Asian subjects (20 eyes) using an interferometer (LipiView® ocular surface interferometer, TearScience Inc, Morrisville, NC). Dry eye symptoms, tear break up time (TBUT) and corneal fluorescein staining were also prospectively evaluated.

RESULTS:

Data for 20 participants are presented for either right or left eye (randomly selected). The mean LLT ± standard deviation of these participants was 53.53 ± 14.59 nm. When a single observer repeated the imaging on the same day, the coefficient of repeatability was 16 nm and the 95% limits of agreement were between -11 nm and 18 nm. When a different observer repeated the scan, the coefficient of repeatability was 13 nm and limits of agreement were -9 nm and 16 nm. LLT was not significantly associated with TBUT, presence of any corneal staining in any corneal zones, or symptomatic status.

CONCLUSION:

With the repeatability of measurements being known, the significance of LLT changes measured by this interferometer may be better interpreted. In this small Asian study, the LLT was lower than previously reported studies.

PMID:
25975974
PMCID:
PMC4462010
DOI:
10.1186/s12886-015-0036-9
[Indexed for MEDLINE]
Free PMC Article

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