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J Clin Endocrinol Metab. 2015 Jul;100(7):2751-7. doi: 10.1210/jc.2014-4562. Epub 2015 May 14.

Severe Obesity in Adolescents and Young Adults Is Associated With Subclinical Cardiac and Vascular Changes.

Author information

1
Cincinnati Children's Hospital Medical Center, The University of Cincinnati, Cincinnati, Ohio 45229.

Abstract

CONTEXT:

Severe obesity is the fastest growing subgroup of obesity in youth.

OBJECTIVE:

We sought to explore the association between severe obesity and subclinical measures of cardiac and vascular structure and function in adolescents and young adults.

DESIGN, SETTING, AND PARTICIPANTS:

This was a cross-sectional comparison of 265 adolescents and young adults with severe obesity (defined as body mass index [BMI] ≥120% of the 95th percentile) to 182 adolescents and young adults with obesity (defined as BMI ≥100-119th of the 95th percentile) at tertiary medical center.

MAIN OUTCOMES:

Noninvasive measures of cardiac and vascular structure and function were assessed.

RESULTS:

Participants were a mean age of 17.9 years, 62% were non-Caucasian, and 68% were female. Systolic blood pressure, fasting insulin, C-reactive protein, IL-6, and frequency of type 2 diabetes were higher in participants with severe obesity (all P < .05). Arterial thickness and stiffness, cardiac structure, and diastolic function were also significantly worse in youth with severe obesity as measured by higher left ventricular mass index, worse diastolic function, higher carotid intima media thickness, and pulse wave velocity and lower brachial distensibility (all P < .05). Regression modeling showed that severe obesity (compared with obesity) was independently associated with each of the above outcomes after adjustment for age, race, sex, blood pressure, lipids, and inflammatory markers (P < .05).

CONCLUSIONS:

Adolescents and young adults with severe obesity have a more adverse cardiovascular risk profile and worse cardiac and vascular structure and function. More importantly, severe obesity is independently associated with these subclinical cardiac and vascular changes.

PMID:
25974736
PMCID:
PMC4490306
DOI:
10.1210/jc.2014-4562
[Indexed for MEDLINE]
Free PMC Article

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