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Redox Biol. 2015 Aug;5:186-194. doi: 10.1016/j.redox.2015.04.004. Epub 2015 Apr 22.

Thiol redox homeostasis in neurodegenerative disease.

Author information

1
UCD School of Biomolecular and Biomedical Science, University College, Dublin, Ireland. Electronic address: gethin.mcbean@ucd.ie.
2
Department of Medical Biochemistry, Akdeniz University School of Medicine, Antalya, Turkey.
3
School of Life and Health Sciences, Aston University, Birmingham, UK.

Abstract

This review provides an overview of the biochemistry of thiol redox couples and the significance of thiol redox homeostasis in neurodegenerative disease. The discussion is centred on cysteine/cystine redox balance, the significance of the xc(-) cystine-glutamate exchanger and the association between protein thiol redox balance and neurodegeneration, with particular reference to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and glaucoma. The role of thiol disulphide oxidoreductases in providing neuroprotection is also discussed.

KEYWORDS:

Cysteine; Glutaredoxin; Glutathione; Neurodegenerative disease; Peroxiredoxin; Thioredoxin

PMID:
25974624
PMCID:
PMC4434181
DOI:
10.1016/j.redox.2015.04.004
[Indexed for MEDLINE]
Free PMC Article

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