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J Immunol Res. 2015;2015:909514. doi: 10.1155/2015/909514. Epub 2015 Apr 20.

Lactobacillus acidophilus suppresses colitis-associated activation of the IL-23/Th17 axis.

Author information

1
Department of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410011, China.
2
Department of Gastroenterology, Second Xiangya Hospital of Central South University, Changsha 410008, China.

Abstract

The aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23/Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of interleukin- (IL-) 17, tumor necrosis factor α (TNFα), IL-23, transforming growth factor β1 (TGFβ1), signal transducer and activator of transcription 3 (STAT3), and phosphorylated (p)-STAT3 was examined by RT-PCR, Western blotting, and immunohistochemical analysis. And the results showed that administration of L. acidophilus suppressed Th17 cell-mediated secretion of proinflammatory cytokine IL-17 through downregulation of IL-23 and TGFβ1 expression and downstream phosphorylation of p-STAT3.

PMID:
25973440
PMCID:
PMC4417982
DOI:
10.1155/2015/909514
[Indexed for MEDLINE]
Free PMC Article

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