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J Immunol Res. 2015;2015:257879. doi: 10.1155/2015/257879. Epub 2015 Apr 20.

Vitamin D and atopic dermatitis in childhood.

Author information

1
Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 11 Piazza Giulio Cesare, 70124 Bari, Italy.
2
Section of Dermatology, Vito Fazzi Hospital, Piazza Filippo Muratore, 73100 Lecce, Italy.

Abstract

Vitamin D features immunomodulatory effects on both the innate and adaptive immune systems, which may explain the growing evidence connecting vitamin D to allergic diseases. A wealth of studies describing a beneficial effect of vitamin D on atopic dermatitis (AD) prevalence and severity are known. However, observations linking high vitamin D levels to an increased risk of developing AD have also been published, effectively creating a controversy. In this paper, we review the existing literature on the association between AD and vitamin D levels, focusing on childhood. As of today, the role of vitamin D in AD is far from clear; additional studies are particularly needed in order to confirm the promising therapeutic role of vitamin D supplementation in childhood AD.

PMID:
25973433
PMCID:
PMC4417995
DOI:
10.1155/2015/257879
[Indexed for MEDLINE]
Free PMC Article

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