Format

Send to

Choose Destination
Jundishapur J Microbiol. 2015 Jan 14;8(3):e21444. doi: 10.5812/jjm.21444. eCollection 2015 Mar.

Comparison of Serum Hepatitis B Virus DNA and HBsAg Levels Between HBeAg-Negative and HBeAg-Positive Chronic Hepatitis B Patients.

Author information

1
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, IR Iran ; Middle East Liver Diseases (MELD) Center, Tehran, IR Iran ; Iran Hepatitis Network, Tehran, IR Iran.
2
Middle East Liver Diseases (MELD) Center, Tehran, IR Iran ; Iran Hepatitis Network, Tehran, IR Iran.

Abstract

BACKGROUND:

Chronic hepatitis B consists of different clinical phases. Laboratory and histological assessments can help differentiate the clinical phases of this disease and thus lead to better management.

OBJECTIVES:

This study was conducted to determine laboratory and histological characteristics of HBeAg-negative and HBeAg-positive chronic hepatitis B patients.

PATIENTS AND METHODS:

In this study, we evaluated 151 treatment naive chronic hepatitis B patients and grouped them according to their HBeAg status. Serum hepatitis B virus (HBV) DNA and HBsAg levels were measured, and liver function tests, and liver biopsy were performed for the study population.

RESULTS:

There was a significant difference in age, and HBV DNA and HBsAg levels between HBeAg-negative and HBeAg-positive groups yet there was no statistically significant difference in sex, liver function tests, grading and staging of liver biopsy between the groups. Hepatitis B virus DNA and HBsAg levels were correlated in both HBeAg-negative and HBeAg-positive chronic hepatitis B patients.

CONCLUSIONS:

We concluded that chronic hepatitis B patients had different HBV DNA and HBsAg levels according to their HBeAg status.

KEYWORDS:

HBeAg; HBsAg; Hepatitis B

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center