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Saudi J Biol Sci. 2015 May;22(3):327-31. doi: 10.1016/j.sjbs.2014.11.014. Epub 2014 Nov 20.

Angiotensin converting enzyme gene polymorphism studies: A case-control study.

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Department of Biology, Faculty of Science, King Abdulaziz University, P O Box 42671, Jeddah 21551, Saudi Arabia.


Mild gestational hyperglycemia (MGH) is a very common complication of pregnancy that is characterized by intolerance to glucose. The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism to MGH has been previously reported. In this study, we evaluated the association between ACE polymorphism and the risk of MGH in a Saudi population. We conducted a case-control study in a population of 100 MGH patients and 100 control subjects. ACE gene polymorphism was analyzed by the novel approach of tetraprimer amplification refractory mutation system (ARMS)-polymerase chain reaction (PCR). The frequency of ACE polymorphism was not associated with either alleles or genotypes in MGH patients. Glucose concentration was found to be significantly associated with the MGH group. Our study suggests that ACE genotypes were not associated with ACE polymorphism in a Saudi population.


ACE; Insertion and deletion polymorphism; MGH

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