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Eur J Cancer. 2015 Jul;51(11):1444-55. doi: 10.1016/j.ejca.2015.04.014. Epub 2015 May 9.

Childhood central nervous system tumours: Incidence and time trends in 13 Southern and Eastern European cancer registries.

Author information

1
Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece.
2
National Cancer Registry of Ukraine, National Institute of Cancer, Kyiv, Ukraine.
3
Belarusian Research Center for Pediatric Oncology, Hematology and Immunology , Childhood Cancer Subregistry of Belarus, Minsk, Belarus.
4
Bulgarian National Cancer Registry, National Oncology Hospital, Sofia, Bulgaria.
5
Institute of Public Health of Serbia, Belgrade, Serbia.
6
Izmir Cancer Registry, Izmir Hub, Izmir & Hacettepe University Institute of Public Health, Ankara, Turkey.
7
North Region Cancer Registry of Portugal (RORENO), Portuguese Oncology Institute of Porto, Portugal.
8
Croatian National Cancer Registry, Croatian Institute of Public Health, Zagreb, Croatia.
9
Cancer Registry of Republic of Slovenia, Institute of Oncology, Ljubljana, Slovenia.
10
Registo Oncológico Regional do Centro, Instituto Português de Oncologia de Coimbra, Francisco Gentil E.P.E, Coimbra, Portugal.
11
Cyprus Cancer Registry-Health Monitoring Unit, Ministry of Health, Nicosia, Cyprus.
12
Northeast Regional Cancer Registry, Regional Center of Public Health, 14 Victor Babes Street, 700465 Iasi, Romania.
13
Regional Cancer Registry of Cluj, Oncological Institute "Ion Chiricuta", Cluj-Napoca, Romania.
14
Oncology Department, "Mitera" Childrens Hospital, ErythrouStavrou 6 Marousi, Athens, Greece.
15
2nd Department of Pediatrics, Aristotelion University of Thessaloniki, AHEPA General Hospital, Thessaloniki, Greece.
16
Haematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, "Aghia Sophia" Children's Hospital, Athens, Greece.
17
Department of Pediatric Haematology-Oncology, "Aghia Sophia" Children's Hospital, Athens, Greece.
18
Department of Pediatric Hematology-Oncology, "Pan. & Agl. Kyriakou" Children's Hospital, Athens, Greece.
19
Department of Pediatric Hematology-Oncology, University of Crete, University Hospital of Heraklion, Heraklion, Greece.
20
Department of Pediatric Hematology and Oncology, Hippokration Hospital, Thessaloniki, Greece.
21
Department of Neurosurgery, "G. Gennimatas" Athens General Hospital, Athens, Greece.
22
Department of Neurosurgery, "Mitera" Childrens Hospital, Erythrou Stavrou 6 Marousi, Athens, Greece.
23
Department of Neurosurgery, University Hospital of Heraklion, Heraklion, Crete, Greece.
24
Department of Neurosurgery, St. Luke's Hospital, Panorama, Thessaloniki, Greece.
25
First Department of Radiology, Aretaieion Hospital, Medical School, University of Athens, Athens, Greece.
26
2nd Department of Radiology, Radiotherapy Unit, Medical School, National Kapodistrian University of Athens, Athens, Greece.
27
Department of Radiology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
28
Department of Pathology, "G. Gennimatas" Athens General Hospital, Athens, Greece.
29
Department of Pathology, Hygeia Hospital, Athens, Greece.
30
Histopathology Department, "Aghia Sophia" Children's Hospital, Athens, Greece.
31
Histopathology Department, "Pan. & Agl. Kyriakou" Children's Hospital, Athens, Greece.
32
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
33
Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France.
34
Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece. Electronic address: epetrid@med.uoa.gr.

Abstract

AIM:

Following completion of the first 5-year nationwide childhood (0-14 years) registration in Greece, central nervous system (CNS) tumour incidence rates are compared with those of 12 registries operating in 10 Southern-Eastern European countries.

METHODS:

All CNS tumours, as defined by the International Classification of Childhood Cancer (ICCC-3) and registered in any period between 1983 and 2014 were collected from the collaborating cancer registries. Data were evaluated using standard International Agency for Research on Cancer (IARC) criteria. Crude and age-adjusted incidence rates (AIR) by age/gender/diagnostic subgroup were calculated, whereas time trends were assessed through Poisson and Joinpoint regression models.

RESULTS:

6062 CNS tumours were retrieved with non-malignant CNS tumours recorded in eight registries; therefore, the analyses were performed on 5191 malignant tumours. Proportion of death certificate only cases was low and morphologic verification overall high; yet five registries presented >10% unspecified neoplasms. The male/female ratio was 1.3 and incidence decreased gradually with age, apart from Turkey and Ukraine. Overall AIR for malignant tumours was 23/10(6) children, with the highest rates noted in Croatia and Serbia. A statistically significant AIR increase was noted in Bulgaria, whereas significant decreases were noted in Belarus, Croatia, Cyprus and Serbia. Although astrocytomas were overall the most common subgroup (30%) followed by embryonal tumours (26%), the latter was the predominant subgroup in six registries.

CONCLUSION:

Childhood cancer registration is expanding in Southern-Eastern Europe. The heterogeneity in registration practices and incidence patterns of CNS tumours necessitates further investigation aiming to provide clues in aetiology and direct investments into surveillance and early tumour detection.

KEYWORDS:

Age distribution; Central nervous system neoplasms; Child; Europe; Gender; Incidence; Registries; Time factors

PMID:
25971531
DOI:
10.1016/j.ejca.2015.04.014
[Indexed for MEDLINE]

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