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J Neurotrauma. 2016 Jan 1;33(1):157-61. doi: 10.1089/neu.2014.3805. Epub 2015 Jul 17.

Cavum Septum Pellucidum in Retired American Pro-Football Players.

Author information

1
1 Memory and Aging Center, Department of Neurology, University of California , San Francisco, San Francisco, California.
2
2 Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center , San Francisco, California.
3
3 Department of Radiology and Biomedical Imaging, University of California , San Francisco, San Francisco, California.
4
4 Department of Neurosurgery, University of California , San Francisco, San Francisco, California.
5
5 Department of Epidemiology and Biostatistics, University of California , San Francisco, San Francisco, California.
6
6 Department of Psychiatry, University of California , San Francisco, San Francisco, California.

Abstract

Previous studies report that cavum septum pellucidum (CSP) is frequent among athletes with a history of repeated traumatic brain injury (TBI), such as boxers. Few studies of CSP in athletes, however, have assessed detailed features of the septum pellucidum in a case-control fashion. This is important because prevalence of CSP in the general population varies widely (2% to 85%) between studies. Further, rates of CSP among American pro-football players have not been described previously. We sought to characterize MRI features of the septum pellucidum in a series of retired pro-football players with a history of repeated concussive/subconcussive head traumas compared with controls. We retrospectively assessed retired American pro-football players presenting to our memory clinic with cognitive/behavioral symptoms in whom structural MRI was available with slice thickness ≤2 mm (n=17). Each player was matched to a memory clinic control patient with no history of TBI. Scans were interpreted by raters blinded to clinical information and TBI/football history, who measured CSP grade (0-absent, 1-equivocal, 2-mild, 3-moderate, 4-severe) and length according to a standard protocol. Sixteen of 17 (94%) players had a CSP graded ≥2 compared with 3 of 17 (18%) controls. CSP was significantly higher grade (p<0.001) and longer in players than controls (mean length±standard deviation: 10.6 mm±5.4 vs. 1.1 mm±1.3, p<0.001). Among patients presenting to a memory clinic, long high-grade CSP was more frequent in retired pro-football players compared with patients without a history of TBI.

KEYWORDS:

concussion; magnetic resonance imaging; septum pellucidum; traumatic brain injury

PMID:
25970145
PMCID:
PMC4696427
DOI:
10.1089/neu.2014.3805
[Indexed for MEDLINE]
Free PMC Article

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