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Clin Infect Dis. 2015 Sep 1;61(5):695-703. doi: 10.1093/cid/civ378. Epub 2015 May 12.

Variants in the Mannose-binding Lectin Gene MBL2 do not Associate With Sepsis Susceptibility or Survival in a Large European Cohort.

Author information

1
Wellcome Trust Centre for Human Genetics, University of Oxford.
2
John Radcliffe Hospital, Oxford.
3
Section of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London.
4
School of Clinical and Experimental Medicine, University of Birmingham, United Kingdom.
5
Hospital Cochin, Paris, France.
6
Department of Anaesthesiology and Pain Medicine, Bern University Hospital and University of Bern, Switzerland.
7
Barts and The London School of Medicine Queen Mary University of London, United Kingdom.

Abstract

BACKGROUND:

Sepsis is an increasingly common condition, which continues to be associated with unacceptably high mortality. A large number of association studies have investigated susceptibility to, or mortality from, sepsis for variants in the functionally important immune-related gene MBL2. These studies have largely been underpowered and contradictory.

METHODS:

We genotyped and analyzed 4 important MBL2 single nucleotide polymorphisms (SNPs; rs5030737, rs1800450, rs1800451, and rs7096206) in 1839 European community-acquired pneumonia (CAP) and peritonitis sepsis cases, and 477 controls from the United Kingdom. We analyzed the following predefined subgroups and outcomes: 28-day and 6 month mortality from sepsis due to CAP or peritonitis combined, 28-day mortality from CAP sepsis, peritonitis sepsis, pneumococcal sepsis or sepsis in younger patients, and susceptibility to CAP sepsis or pneumococcal sepsis in the United Kingdom.

RESULTS:

There were no significant associations (all P-values were greater than .05 after correction for multiple testing) between MBL2 genotypes and any of our predefined analyses.

CONCLUSIONS:

In this large, well-defined cohort of immune competent adult patients, no associations between MBL2 genotype and sepsis susceptibility or outcome were identified.

KEYWORDS:

MBL; association study; genetics; mannose-binding lectin; sepsis

PMID:
25969530
PMCID:
PMC4530723
DOI:
10.1093/cid/civ378
[Indexed for MEDLINE]
Free PMC Article

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