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Nat Commun. 2015 May 13;6:7041. doi: 10.1038/ncomms8041.

Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese.

Author information

1
1] Shandong Gout Clinical Medical Center, Qingdao 266003, China [2] Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China.
2
1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China [2] Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.
3
Department of Rheumatology and Immunology of the Affiliated Hospital, North Sichuan Medical College, Nanchong 737000, China.
4
The Affiliated Huashan Hospital of Fudan University, Shanghai 20040, China.
5
1] Shandong Gout Clinical Medical Center, Qingdao 266003, China [2] Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China [3] Henry Ford Immunology Program, Henry Ford Health System, 1 Ford Place, Detroit, Minnesota 48202, USA.
6
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.
7
Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, P.R. China.
8
1] Henry Ford Immunology Program, Henry Ford Health System, 1 Ford Place, Detroit, Minnesota 48202, USA [2] Department of Dermatology, Henry Ford Health System, 1 Ford Place, Detroit, Michigan 48202, USA [3] Department of Internal Medicine, Henry Ford Health System, 1 Ford Place, Detroit, Michigan 48202, USA.
9
Department of Urology, The Affiliated Hospital of Medical College Qingdao University, Qingdao 266003, China.
10
Department of Oncology, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China.
11
Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, P.R. China.
12
1] Shandong Gout Clinical Medical Center, Qingdao 266003, China [2] Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China [3] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China [4] Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.

Abstract

Gout is one of the most common types of inflammatory arthritis, caused by the deposition of monosodium urate crystals in and around the joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum urate concentrations. However, hyperuricemia alone is not sufficient for the development of gout arthritis. Here we conduct a multistage GWAS in Han Chinese using 4,275 male gout patients and 6,272 normal male controls (1,255 cases and 1,848 controls were genome-wide genotyped), with an additional 1,644 hyperuricemic controls. We discover three new risk loci, 17q23.2 (rs11653176, P=1.36 × 10(-13), BCAS3), 9p24.2 (rs12236871, P=1.48 × 10(-10), RFX3) and 11p15.5 (rs179785, P=1.28 × 10(-8), KCNQ1), which contain inflammatory candidate genes. Our results suggest that these loci are most likely related to the progression from hyperuricemia to inflammatory gout, which will provide new insights into the pathogenesis of gout arthritis.

PMID:
25967671
PMCID:
PMC4479022
DOI:
10.1038/ncomms8041
[Indexed for MEDLINE]
Free PMC Article

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