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Genet Mol Res. 2015 Apr 27;14(2):3939-47. doi: 10.4238/2015.April.27.8.

High-resolution color doppler ultrasound examination and related risk factor analysis of lower extremity vasculopathy in type 2 diabetes patients.

Author information

1
Second Division, Department of Endocrinology, Hebei Cangzhou Central Hospital, Hebei, China jxgycn@163.com.
2
Second Division, Department of Endocrinology, Hebei Cangzhou Central Hospital, Hebei, China.

Abstract

This study aims to investigate the value of high-resolution color Doppler ultrasonography (HR-CDU) in the evaluation of lower-extremity vasculopathy (LEV) and its related risk factors in type 2 diabetes mellitus (T2DM) patients. Two hundred forty T2DM patients were selected, who underwent lower-extremity arterial HR-CDU. The patients were divided into the LEV group (V group) and the nonvasculopathy group (A group). The V group was then divided into the mild (B group), moderate (C group), and severe (D group) subgroups. The relevant clinical parameters were simultaneously recorded. The results showed that the lesion-positive detection rate of HR-CDU was significantly higher than that of clinical examination. The age, disease duration, smoking history, blood pressure, blood sugar, fibrinogen (FIB), C-reactive protein (CRP), uric acid (UA), and urinary albumin excretion (UAE) in the V group were higher than in the N group. In the logistic regression analysis, smoking history, age, disease duration, FIB, UA, and fasting blood glucose were independent risk factors of T2DM LEV. The incidence of LEV in T2DM patients increased significantly with increasing age, UA, FIB, CRP, UAE, disease duration, and smoking history, and the vasculopathy level became more severe. In conclusion, age, disease duration, smoking history, blood pressure, blood sugar, FIB, CRP, UA, and UAE are the related risk factors of LEV in T2DM patients.

PMID:
25966165
DOI:
10.4238/2015.April.27.8
[Indexed for MEDLINE]
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