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Fitoterapia. 2015 Jun;103:294-8. doi: 10.1016/j.fitote.2015.05.005. Epub 2015 May 9.

Nor-lupane triterpenoid and guaiane sesquiterpenoids from Schefflera venulosa.

Author information

1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China; Faculty of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, PR China.
2
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
3
Faculty of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, PR China. Electronic address: dongwenming88@sina.com.
4
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. Electronic address: qinshizhao@mail.kib.ac.cn.

Abstract

A novel nor-lupane triterpenoid, 3-oxo-29α-hydroxy-17β,20-epoxy-28-norlupane (1), and two new guaiane sesquiterpenoids, schvenols A-B (2-3), has been isolated from leaves of Schefflera venulosa. Structures of the new compounds were elucidated on the basis of their spectroscopic methods, including 1D and 2D NMR techniques. And the structure of 1 was further confirmed by the X-ray diffraction analysis. None of the compounds showed inhibitory effects on NO release in LPS-stimulated RAW 264.7 macrophage cell line.

KEYWORDS:

3-Oxo-29α-hydroxy-17β,20-epoxy-28-norlupane; Nor-lupane triterpenoid; Schefflera venulosa; Schvenols A–B; Sesquiterpenoids

PMID:
25964186
DOI:
10.1016/j.fitote.2015.05.005
[Indexed for MEDLINE]

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