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Biol Psychiatry. 2016 Feb 15;79(4):266-73. doi: 10.1016/j.biopsych.2015.03.025. Epub 2015 Apr 2.

Transcutaneous Vagus Nerve Stimulation Modulates Default Mode Network in Major Depressive Disorder.

Author information

1
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.; Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
2
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.. Electronic address: rongpj@hotmail.com.
3
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
4
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
5
Huguosi Hospital, Beijing University of Chinese Medicine, Beijing.
6
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.; Hospital of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing.
7
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Acupuncture & Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu.
8
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
9
Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Abstract

BACKGROUND:

Depression is the most common form of mental disorder in community and health care settings and current treatments are far from satisfactory. Vagus nerve stimulation (VNS) is a Food and Drug Administration approved somatic treatment for treatment-resistant depression. However, the involvement of surgery has limited VNS only to patients who have failed to respond to multiple treatment options. Transcutaneous VNS (tVNS) is a relatively new, noninvasive VNS method based on the rationale that there is afferent/efferent vagus nerve distribution on the surface of the ear. The safe and low-cost characteristics of tVNS have the potential to significantly expand the clinical application of VNS.

METHODS:

In this study, we investigated how tVNS can modulate the default mode network (DMN) functional connectivity (FC) in mild or moderate major depressive disorder (MDD) patients. Forty-nine MDD patients were recruited and received tVNS or sham tVNS (stVNS) treatments.

RESULTS:

Thirty-four patients completed the study and were included in data analysis. After 1 month of tVNS treatment, the 24-item Hamilton Depression Rating Scale score reduced significantly in the tVNS group as compared with the stVNS group. The FC between the DMN and anterior insula and parahippocampus decreased; the FC between the DMN and precuneus and orbital prefrontal cortex increased compared with stVNS. All these FC increases are also associated with 24-item Hamilton Depression Rating Scale reduction.

CONCLUSIONS:

tVNS can significantly modulate the DMN FC of MDD patients; our results provide insights to elucidate the brain mechanism of tVNS treatment for MDD patients.

KEYWORDS:

Default mode network; Functional connectivity; Major depressive disorder; Transcutaneous vagus nerve stimulation; Vagus nerve stimulation; fMRI

PMID:
25963932
PMCID:
PMC4838995
DOI:
10.1016/j.biopsych.2015.03.025
[Indexed for MEDLINE]
Free PMC Article

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