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Int J Oncol. 2015 Jul;47(1):5-15. doi: 10.3892/ijo.2015.2998. Epub 2015 May 11.

Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review).

Author information

1
Experimental Tumorpathology, Institute of Pathology, FAU Erlangen-Nürnberg, 91054 Erlangen, Germany.
2
Department of Medicine 1, University Hospital Erlangen, FAU Erlangen-Nürnberg, Kussmaul Campus for Medical Research, 91052 Erlangen, Germany.
3
Institute of Pathology, FAU Erlangen-Nürnberg, 91054 Erlangen, Germany.

Abstract

The cytoskeleton-associated serine/threonine kinase death-associated protein kinase (DAPK) has been described as a cancer gene chameleon with functional antagonistic duality in a cell type and context specific manner. The broad range of interaction partners and substrates link DAPK to inflammatory processes especially in the gut. Herein we summarize our knowledge on the role of DAPK in different cell types that play a role under inflammatory conditions in the gut. Besides some promising experimental data suggesting DAPK as an interesting drug target in inflammatory bowel disease there are many open questions regarding direct evidence for a role of DAPK in intestinal inflammation.

PMID:
25963636
PMCID:
PMC4485655
DOI:
10.3892/ijo.2015.2998
[Indexed for MEDLINE]
Free PMC Article

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