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DNA Repair (Amst). 2015 Aug;32:10-6. doi: 10.1016/j.dnarep.2015.04.008. Epub 2015 May 1.

The rise and fall of poly(ADP-ribose): An enzymatic perspective.

Author information

1
Department of Biochemistry & Molecular Biology, Sydney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: john.pascal@jefferson.edu.
2
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: tome@biochem.wustl.edu.

Abstract

Human cells respond to DNA damage with an acute and transient burst in production of poly(ADP-ribose), a posttranslational modification that expedites damage repair and plays a pivotal role in cell fate decisions. Poly(ADP-ribose) polymerases (PARPs) and glycohydrolase (PARG) are the key set of enzymes that orchestrate the rise and fall in cellular levels of poly(ADP-ribose). In this perspective, we focus on recent structural and mechanistic insights into the enzymes involved in poly(ADP-ribose) production and turnover, and we highlight important questions that remain to be answered.

KEYWORDS:

ADP-ribose; DNA damage response; MARG; PARG; PARP; Poly(ADP-ribose)

PMID:
25963443
PMCID:
PMC4522361
DOI:
10.1016/j.dnarep.2015.04.008
[Indexed for MEDLINE]
Free PMC Article

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