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Biofactors. 2015 May 6;41(3):190-7. doi: 10.1002/biof.1213. Epub 2015 May 12.

Taurine, a major amino acid of oyster, enhances linear bone growth in a mouse model of protein malnutrition.

Author information

1
Department of Pharmacology, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Republic of Korea.
2
Department of Computer Aided Mechanical Engineering, Sohae College, Gunsan, Jeonbuk, 573-717, Republic of Korea.
3
Du Wha Com., Deokjeong-ri, Samseong-myeon, Eumseong-gun, Chungbuk, 369-833, Republic of Korea.
4
Oriental Bio-herb Research Institute, Kangwon National University, Chuncheon, 200-701, Republic of Korea.
5
Inflammatory Disease Research Center and Biochip Research Center, Hoseo University, 165 Sechul-ri, Baebang-myun, Asan, Chungnam, 336-795, Republic of Korea.

Abstract

Oysters (Oys) contain various beneficial components, such as, antioxidants and amino acids. However, the effects of Oys or taurine (Tau), a major amino acid in Oys on bone growth have not been determined. In the present study, we evaluated the effects of Oys or Tau on linear bone growth in a mouse model of protein malnutrition. To make the protein malnutrition in a mouse, we used a low protein diet. Growth plate thickness was increased by Oys or Tau. Bone volume/tissue volume, trabecular thickness, trabecular number, connection density, and total porosity were also improved by Oys or Tau. Oys or Tau increased insulin-like growth factor-1 (IGF-1) levels in serum, liver, and tibia-growth plate. Phosphorylations of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) were increased by Oys and by Tau. These findings show that Oys or Tau may increase growth plate thickness by elevating IGF-1 levels and by promoting the phosphorylations of JAK2-STAT5, and suggest that Oys or Tau are growth-promoting substances of potential use in the food and pharmaceutical industries.

KEYWORDS:

IGF-1; JAK2-STAT5; growth plate; oysters; taurine

PMID:
25963419
DOI:
10.1002/biof.1213
[Indexed for MEDLINE]

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